Rigidity guided cell attachment on inkjet-printed patterns
Journal
ACS Applied Materials and Interfaces
Journal Volume
4
Journal Issue
7
Pages
3335-3339
Date Issued
2012
Author(s)
Liao, Y.-C.
Ma, Y.-T.
Huang, C.-H.
Yu, J.
Hsiao, H.-M.
Liao, Ying-Chih
Ma, Yun-Ting
Huang, Chi-Hui
Yu, Jiashing
Hsiao, Hao-Ming
Abstract
A new approach is presented to control cell attachment behavior on biocompatible substrates. Multiple layers of polylactic acid (PLA) were inkjet-printed on dry alginate films to create composite surfaces with rigidity variation. The printed films were submerged in cell culture medium and fibroblast 3T3-L1 cells were cultured on the printed films. 3T3-L1 cells were found to preferentially adhere on PLA surfaces with higher rigidity. The same approach was also used to create various cell attachment patterns. This study provides a new methodology to fabricate biodegradable matrix for favorable cell adhesion or patterning.
Type
journal article