RANTES-403 polymorphism is associated with reduced risk of gastric cancer in women
Journal
Journal of Gastroenterology
Journal Volume
43
Journal Issue
2
Pages
115-123
Date Issued
2008
Author(s)
Lin J.-T.
Huang S.-P.
Wu C.-Y.
Abstract
Background: Men are more susceptible to gastric cancer (GC) than women. However, the genetic factors associated with the sex difference are not well understood. Chemokines have been shown to modulate tumor behavior, and the sex-specific effect of the chemokine polymorphisms on the host susceptibility to several diseases has been reported. We aimed to determine the role of chemokine polymorphisms on host susceptibility to GC, with special interest on their sex-specific effect. Methods: A hospital-based case-control study, including 177 patients with GC and 217 age-matched unaffected healthy controls, was performed in three major tertiary care hospitals. Genotyping for regulated upon activation, normal T-cell expressed and secreted (RANTES) -403 A/G and -28 C/G, CC chemokine receptor 5 (CCR5) deletion, and CCR2-V64I was performed using peripheral blood DNA. Results: The RANTES -403 GA and AA genotypes were independently associated with a 2.3-fold reduced risk of developing GC (OR = 0.44, 95% CI 0.22-0.90, P = 0.025) compared with GG genotype in women, but not in men. The RANTES -28C/G and CCR2-V64I polymorphisms were not associated with different risk of developing GC. The tumor stage, histological features, and survival rate were not different when stratified by RANTES -403 and -28 and CCR2-V64I genotypes. Conclusions: Our data indicate that women who inherit A allele at RANTES -403 may be at reduced risk of GC. ? Springer Japan 2008.
SDGs
Other Subjects
chemokine receptor CCR2; chemokine receptor CCR5; genomic DNA; RANTES; adult; aged; article; cancer risk; cancer staging; cancer survival; case control study; confidence interval; controlled study; female; gene deletion; genetic susceptibility; genotype; histopathology; human; major clinical study; male; priority journal; protein expression; protein function; protein polymorphism; protein secretion; risk assessment; sex difference; stomach cancer; stomach carcinogenesis; survival rate; T lymphocyte activation; Aged; Case-Control Studies; Chemokine CCL5; Female; Genetic Predisposition to Disease; Humans; Immunohistochemistry; Middle Aged; Polymorphism, Genetic; Receptors, CCR2; Risk Assessment; Sex Factors; Stomach Neoplasms; Survival Analysis
Type
journal article