Low-toxicity FePt nanoparticles for the targeted and enhanced diagnosis of breast tumors using few centimeters deep whole-body photoacoustic imaging
Journal
PHOTOACOUSTICS
Journal Volume
19
Pages
100179
Date Issued
2020
Author(s)
Abstract
A considerable amount of early breast tumors grown at a depth over 2 cm in breast tissues. With high near-infrared absorption of iron-platinum (FePt) nanoparticles, we achieved few centimeters deep photoacoustic (PA) imaging for the diagnosis of breast tumors. The imaging depth can extend over 5 cm in chicken breast tissues at the low laser energy density of 20 mJ/cm2 (? ANSI safety limit). After anti-VEGFR conjugation and the tail-vein injection, we validated their targeting on tumor sites by the confocal microscopy and PA imaging. Using a home-made whole-body in vivo PA imaging, we found that the nanoparticles were rapidly cleared away from the site of the tumor and majorly metabolized through the liver. These results validated the clinical potential of the FePt nanoparticles in the low-toxicity PA theragnosis of early breast cancer and showed the capacity of our whole-body PA imaging technique on monitoring the dynamic biodistribution of nanoparticles in the living body. ? 2020 The Author(s)
Subjects
Breast cancer; FePt nanoparticles; Imaging depth; Whole-body photoacoustic imaging
SDGs
Other Subjects
Binary alloys; Diagnosis; Histology; Infrared devices; Iron alloys; Laser safety; Light absorption; Nanoparticles; Platinum alloys; Toxicity; Tumors; Biodistributions; Breast tissues; Early breast cancer; Fe-Pt nanoparticle; Low laser energy density; Near-infrared absorption; Photo-acoustic imaging; Tail vein injections; Medical imaging
Type
journal article