Magnesium Enhanced Fibrinolytic Activity of Protease from Schizophyllum commune
Resource
Taiwania, 55(2), 117-122
Journal
Taiwania
Journal Volume
55
Journal Issue
2
Pages
117-122
Date Issued
2010-06
Date
2010-06
Author(s)
Lu, C.L.
Chen, S.N.
Abstract
Prevention and therapy of thrombotic diseases have attracted much attention in developed countries during recent years. Investigators have been looking for cheaper and safer thrombolytic agents for therapy of thrombotic diseases. Recently, we have discovered a fibrinolytic protease from Schizophyllum commune. In this study, the protease was proven to degrade blood clot effectively. Seven divalent metal ions were used to test the selectiveness on enhancing protease activity. The treated rat blood was traced by thromboelastography to assess the viscoelastic properties of whole blood. As the result, fibrinolytic activity of the protease was enhanced remarkably by Mg2+ in reducing the strength of blood clot and showed the innovative anti-thrombotic effects. This is the first study of anti-thrombotic effects from fungal-derived fibrinolytic protease using thromboelastography and delineates the efficacy of magnesium supplementation in enhancement of thrombolytic activity from S. commune fibrinolytic protease.
Subjects
Fibrinolytic protease
Schizophyllum commune
Magnesium
Anti-thrombotic
Thromboelastography
溶纖蛋白?
?褶菌
鎂?子
抗血栓形成
血液血栓彈?圖。
Type
journal article
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