Acremonium pyomyositis in a pediatric patient with acute leukemia
Journal
Pediatric Blood and Cancer
Journal Volume
44
Journal Issue
5
Pages
521-524
Date Issued
2005
Author(s)
Abstract
Invasive Acremonium infection in humans is rare. We report a patient with leukemia who developed pyomyositis due to Acremonium species. Painful cutaneous nodules and severe myalgia were the first clinical manifestations during the neutropenic stage after chemotherapy. Magnetic resonance image (MRI) revealed multiple nodular lesions scattered along the intramuscular regions of the lower legs. Culture of an aspiration grew Acremonium species. Surgical drainage was performed. Although all antifungal agents tested showed no in vitro inhibitory activity, we successfully treated this patient with amphotericin B, granulocyte colony-stimulating factor (G-CSF), and surgical drainage. ? 2004 Wiley-Liss, Inc.
SDGs
Other Subjects
amphotericin B; antifungal agent; antineoplastic agent; busulfan; cyclophosphamide; cytarabine; fluconazole; granulocyte macrophage colony stimulating factor; idarubicin; itraconazole; ketoconazole; Acremonium; acute leukemia; adolescent; antifungal activity; article; aspiration; case report; childhood leukemia; clinical feature; disease severity; drug efficacy; female; fungus culture; fungus growth; human; human tissue; in vitro study; leg muscle; myalgia; neutropenia; nonhuman; priority journal; pyomyositis; rare disease; skin nodule; surgical drainage; Acremonium; Acute Disease; Adolescent; Amphotericin B; Drainage; Female; Granulocyte Colony-Stimulating Factor; Humans; Leukemia; Mycoses; Neutropenia; Opportunistic Infections
Type
journal article