Effects of Air Pollution on School Children in Exhaled Breath and Lung Function
Date Issued
2010
Date
2010
Author(s)
Chen, Yung-Kang
Abstract
Expose to air pollution has been associated with eye and respiratory system irritation, allergic and inflamed effects and cardiovascular disease. These symptoms were observable in susceptible groups. In Taipei metropolis, the asthma incidence rate rise yearly in schoolchildren. Therefore, the objective of this study was to investigate exhaled breath VOCs and lung function relevance of the air pollution in asthmatic children. Besides, the lag effect of exposure to particulate matter would also be studied.
The study divided participants into asthmatic and non-asthmatic schoolchildren. Take the exhaled breath and lung function cooperate with the air quality monitor data of EPA Supersite. The thermal desorption GC/MS was used to analyze the exhaled breath and conducted pentane as an indicator of oxidative stress; moreover, the lung function was measured by spirometer. Generalized Estimating Equations (GEEs) was used to examine the repeated measurement of the exhaled breath and lung function affected by air pollution.
As the result, the higher oxidative stress and the lower average lung function in asthmatic children (Pentane=0.106 and 0.095, AG) was observed gender, body mass index (BMI), flu, and air pollutant (SO2, CO, NO, NO2, PM2.5) had significant influence in oxidative stress. Lung function were affected by height, weight, BMI, road, dust, vitamins, and air pollutant (SO2, CO, O3, NO, NO2, PM2.5). Lag effect of PM2.5 exhibit the oxidative stress in Lag10, Lag14, Lag30. The lung function (FVC, FEV1) and Lag5, Lag7, Lag10, Lag14, Lag30 in oxidative stress showed the lag effect of PM10.
Asthmatic children which are susceptible had higher oxidative stress. The effects of air pollution display in oxidative stress and lung function of schoolchildren. The lag effects in oxidative stress and lung function of particulate matter were significant. This study indicated that oxidative stress is a sensitive factor and can reflect the long-term injury of exposure. In addition, the lag effect of PM10 was observed by lung function.
Subjects
Exhaled breath
Oxidative stress
Lung function
Lag effect
Pentane
Type
thesis
File(s)![Thumbnail Image]()
Loading...
Name
ntu-99-R96844016-1.pdf
Size
23.32 KB
Format
Adobe PDF
Checksum
(MD5):e8b17093c0da60e2513d632adfd46c25