Predictors of faster decline of residual renal function in Taiwanese peritoneal dialysis patients
Journal
Peritoneal Dialysis International
Journal Volume
28
Journal Issue
SUPP. 3
Pages
S191-S195
Date Issued
2008
Author(s)
Liao C.-T.
Shiao C.-C.
Chuang H.-F.
Abstract
◆ Objective: Loss of residual renal function (RRF) in peritoneal dialysis (PD) patients is a powerful predictor of mortality. The present study was conducted to determine the predictors of faster decline of RRF in PD patients in Taiwan. ◆ Methods: The study enrolled 270 patients starting PD between January 1996 and December 2005 in a single hospital in Taiwan. We calculated RRF as the mean of the sum of 24-hour urea and creatinine clearance. The slope of the decline of residual glomerular filtration rate (GFR) was the main outcome measure. Data on demographic, clinical, laboratory, and treatment parameters; episodes of peritonitis; and hypotensive events were analyzed by Student t-test, Nann-Whitney U-test, and chi-square, as appropriate. All variables with statistical significance were included in a multivariate linear regression model to select the best predictors (p < 0.05) for faster decline of residual GFR. ◆ Results: All patients commencing PD during the study period were followed for 39.4 ± 24.0 months (median: 35.5 months).The average annual rate of decline of residual GFR was 1.377 ± 1.47 mL/min/m2. On multivariate analysis, presence of diabetes mellitus (p < 0.001), higher baseline residual GFR (p < 0.001), hypotensive events (p = 0.001), use of diuretics (p = 0.002), and episodes of peritonitis (p = 0.043) independently predicted faster decline of residual GFR. Nale sex, old age, larger body mass index, and presence of coronary artery disease or congestive heart failure were also risk factors on univariate analysis. ◆ Conclusions: Our results suggested that diabetes mellitus, higher baseline residual GFR, hypotensive events, and use of diuretics are independently associated with faster decline of residual GFR in PD patients in Taiwan. Copyright ? 2008 International Society for Peritoneal Dialysis Printed in Canada. All rights reserved.
SDGs
Other Subjects
antihypertensive agent; creatinine; diuretic agent; urea; adult; age; body mass; chronic glomerulonephritis; conference paper; congestive heart failure; controlled study; coronary artery disease; creatinine clearance; diabetes mellitus; disease association; drug use; female; glomerulus filtration rate; human; kidney failure; kidney function; kidney function test; major clinical study; male; outcome assessment; peritoneal dialysis; peritonitis; priority journal; residual kidney function; risk assessment; risk factor; sex differentiation; Taiwan; urea blood level; Cohort Studies; Comorbidity; Creatinine; Diabetes Mellitus; Diuretics; Female; Glomerular Filtration Rate; Humans; Hypotension; Kidney Failure, Chronic; Kidney Function Tests; Linear Models; Male; Middle Aged; Multivariate Analysis; Peritoneal Dialysis; Peritonitis; Predictive Value of Tests; Retrospective Studies; Taiwan; Urea
Type
conference paper