Altered glycosylation of Tamm-Horsfall glycoprotein derived from renal allograft recipients leads to changes in its biological function
Journal
Transplant immunology
Journal Volume
18
Journal Issue
3
Pages
237
Date Issued
2008-01
Author(s)
Abstract
Human urinary Tamm-Horsfall glycoprotein (THP) is a pleotropic protein that binds different cytokines and stimulates various immunocompetent cells. It is unclear whether these important functions of THP are altered in renal transplant patients.
Subjects
NF-kappa B p52; proinflammatory cytokine-binding activity; renal allograft transplantation; Tamm-Horsfall glycoprotein (THP); TUMOR NECROSIS FACTOR; POLYMORPHONUCLEAR NEUTROPHILS; TUBULOINTERSTITIAL NEPHRITIS; COMPLEMENT 1Q; PROTEIN BINDS; URINARY-TRACT; UROMODULIN; CELLS; GENE; CARBOHYDRATE
Publisher
ELSEVIER SCIENCE BV
Type
journal article