Production of the secondary metabolites γ-aminobutyric acid and monacolin K by Monascus
Resource
Journal of Industrial Microbiology and Biotechnology 30 (1): 41-46
Journal
Journal of Industrial Microbiology & Biotechnology
Journal Volume
30
Journal Issue
1
Pages
41-46
Date Issued
2003
Date
2003
Author(s)
Abstract
gamma-Aminobutyric acid (GABA), a hypotensive agent, and monacolin K, a cholesterol-lowering drug, can be produced by Monascus spp. Under optimal culture conditions, the products of fermentation using Monascus spp. may serve as a multi-functional dietary supplement and can prevent heart disease. In this study, Monascus purpureus CCRC 31615, the strain with the highest amount of monacolin K, was identified from 16 strains using solid fermentation. Its GABA productivity was particularly high. Addition of sodium nitrate during solid-state fermentation of M. purpureus CCRC 31615 improved the productivity of monacolin K and GABA to 378 mg/kg and 1,267.6 mg/kg, respectively. GABA productivity increased further to 1,493.6 mg/kg when dipotassium hydrophosphate was added to the medium.
Type
journal article
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