Severity of psychosis syndrome and change of metabolic abnormality in chronic schizophrenia patients: Severe negative syndrome may be related to a distinct lipid pathophysiology
Journal
European Psychiatry
Journal Volume
29
Journal Issue
3
Pages
167-171
Date Issued
2014
Author(s)
Abstract
Background: Metabolic abnormality is common among schizophrenia patients. Some metabolic traits were found associated with subgroups of schizophrenia patients. Objectives: We examined a possible relationship between metabolic abnormality and psychosis profile in schizophrenia patients. Method: Three hundred and seventy-two chronic schizophrenia patients treated with antipsychotics for more than 2 years were assessed with the Positive and Negative Syndrome Scale. A set of metabolic traits was measured at scheduled checkpoints between October 2004 and September 2006. Results: Multiple regressions adjusted for sex showed negative correlations between body mass index (BMI) and total score and all subscales; triglycerides (TG) was negatively correlated with total score and negative syndrome, while HDLC was positively correlated with negative syndrome. When sex interaction was concerned, total score was negatively correlated with BMI but not with others; negative syndrome was negatively correlated with BMI and positively with HDLC. No metabolic traits were correlated with positive syndrome or general psychopathology. Conclusions: Loss of body weight is a serious health problem in schizophrenia patients with severe psychosis syndrome, especially the negative syndrome. Schizophrenia patients with severe negative syndrome may have a distinct lipid pathophysiology in comparison with those who were less severe in the domain. ? 2013 Elsevier Masson SAS.
Subjects
Glucose
Lipid
Metabolism
Psychosis
Schizophrenia
SDGs
Other Subjects
atypical antipsychotic agent; cholesterol; glucose; glycosylated hemoglobin; hemoglobin A1c; high density lipoprotein cholesterol; low density lipoprotein cholesterol; triacylglycerol; high density lipoprotein cholesterol; triacylglycerol; adult; article; body mass; cholesterol blood level; disease severity; female; follow up; human; major clinical study; male; mental disease; metabolic disorder; middle aged; multiple regression; negative syndrome; Positive and Negative Syndrome Scale; positive syndrome; priority journal; psychosis; schizophrenia; sex; treatment duration; blood; chronic disease; metabolism; pathophysiology; psychosis; schizophrenia; severity of illness index; syndrome; Taiwan; Adult; Body Mass Index; Cholesterol, HDL; Chronic Disease; Female; Humans; Male; Middle Aged; Psychotic Disorders; Schizophrenia; Severity of Illness Index; Syndrome; Taiwan; Triglycerides
Type
journal article