Differential expression of molecular markers in arsenic- and non-arsenic-related urothelial cancer
Journal
Anticancer Research
Journal Volume
26
Journal Issue
01:00 AM
Pages
375-378
Date Issued
2006
Author(s)
Abstract
Background: Little is known about the mechanisms of arsenic-related urothelial cancer (AsUC). The aim of this study was to reveal the differential expression of molecular markers between AsUC and non-arsenic-related UC (non-AsUC). Materials and Methods: Tissues of AsUC (n=33), non-AsUC (n=20) and normal bladder urothelia from patients with benign diseases (n=4) were examined for multiple selected molecular markers responsible for various cellular functions, including glutathione, GST-π, Bcl-2, p53 and c-Fos. Results: The mean cellular glutathione content of normal mucosal samples (33.4±7.2 μM/mg protein) was significantly higher than either non-AsUC (22.8±1.8, p=0.04) or AsUC (16.4±1.6, p=0.002). The glutathione content of non-AsUC was higher than that of AsUC (p=0.012). The expressions of Bcl-2 and c-Fos in AsUC were significantly higher than those in non-AsUC (p=0.004 and p=0.02, respectively). Conclusion: The carcinogenic pathway for AsUC is different, in part, from that of non-AsUC. Cellular glutathione contents may be down-regulated during urothelial carcinogenesis. Bcl-2 and c-Fos may play important roles in arsenic-mediated carcinogenesis of the urothelium.
SDGs
Other Subjects
arsenic; glutathione; glutathione transferase P1; molecular marker; protein bcl 2; protein c fos; protein p53; arsenic poisoning; arsenic related urothelial cancer; article; bladder cancer; bladder carcinogenesis; bladder disease; cancer risk; controlled study; down regulation; human; human tissue; polyacrylamide gel electrophoresis; priority journal; protein expression; protein function; risk factor; tissue level; Western Europe; Arsenic Poisoning; Environmental Exposure; Glutathione; Glutathione S-Transferase pi; Humans; Proto-Oncogene Proteins c-bcl-2; Tumor Markers, Biological; Tumor Suppressor Protein p53; Urinary Bladder Neoplasms
Type
journal article