Acne-associated syndromes: Models for better understanding of acne pathogenesis
Journal
Journal of the European Academy of Dermatology and Venereology
Journal Volume
25
Journal Issue
6
Pages
637-646
Date Issued
2011
Author(s)
Chen W.
Obermayer-Pietsch B.
Melnik B.C.
Yamasaki O.
Dessinioti C.
Ju Q.
Liakou A.I.
Al-Khuzaei S.
Katsambas A.
Ring J.
Zouboulis C.C.
Abstract
Acne, one of the most common skin disorders, is also a cardinal component of many systemic diseases or syndromes. Their association illustrates the nature of these diseases and is indicative of the pathogenesis of acne. Congenital adrenal hyperplasia (CAH) and seborrhoea-acne-hirsutism-androgenetic alopecia (SAHA) syndrome highlight the role of androgen steroids, while polycystic ovary (PCO) and hyperandrogenism-insulin resistance-acanthosis nigricans (HAIR-AN) syndromes indicate insulin resistance in acne. Apert syndrome with increased fibroblast growth factor receptor 2 (FGFR2) signalling results in follicular hyperkeratinization and sebaceous gland hypertrophy in acne. Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) and pyogenic arthritis-pyoderma gangrenosum-acne (PAPA) syndromes highlight the attributes of inflammation to acne formation. Advances in the understanding of the manifestation and molecular mechanisms of these syndromes will help to clarify acne pathogenesis and develop novel therapeutic modalities. ? 2010 European Academy of Dermatology and Venereology and Venereology.
SDGs
Other Subjects
androgen; antiandrogen; calcitonin; contraceptive agent; corticosteroid derivative; cyclosporin A; dapsone; dexamethasone; fibroblast growth factor receptor 2; fludrocortisone; glucocorticoid; hydroxyprogesterone; infliximab; insulin sensitizing agent; isotretinoin; leflunomide; methotrexate; nonsteroid antiinflammatory agent; prednisolone; recombinant interleukin 1 receptor blocking agent; retinoic acid; salazosulfapyridine; acne; acrocephalosyndactyly; alternative medicine; autoinflammatory disease; bedtime dosage; congenital adrenal hyperplasia; disease association; human; hyperandrogenism; hyperandrogenism insulin resistance acanthosis nigrican syndrome; hypoaldosteronism; insulin resistance; low drug dose; ovary polycystic disease; PAPA syndrome; pathogenesis; priority journal; pustulosis; review; SAPHO syndrome; seborrhea; seborrhoea acne hirsutism androgenetic alopecia syndrome; signal transduction; systemic disease; treatment response; unspecified side effect; Acanthosis Nigricans; Acne Vulgaris; Acquired Hyperostosis Syndrome; Acrocephalosyndactylia; Adrenal Hyperplasia, Congenital; Alopecia; Arthritis, Infectious; Dermatitis, Seborrheic; Female; Hirsutism; Humans; Hyperandrogenism; Insulin Resistance; Polycystic Ovary Syndrome; Pyoderma Gangrenosum; Syndrome
Type
review