CAUSES OF DEATH AND ASSOCIATED FACTORS AMONG PATIENTS WITH NON- INSULIN-DEPENDENT DIABETES MELLITUS IN TAIPEI, TAIWAN
Resource
DIABETES RESEARCH AND CLINICAL PRACTICE v.43 n.2 pp.101-109
Journal
DIABETES RESEARCH AND CLINICAL PRACTICE
Journal Volume
v.43
Journal Issue
n.2
Pages
101-109
Date Issued
1999
Date
1999
Author(s)
Chen, K.T.
Chen, C.J.
Fuh, M.M.-T.
Narayan, K.M.V.
Abstract
A cohort of 766 patients with non-insulin-dependent diabetes
mellitus (NIDDM) from a general teaching hospital in Taipei
, Taiwan were followed prospectively to assess survival
experience and associated risk factors. Data were abstracted
from the medical records and additional information was
obtained from patients or their closest relatives using a
structured questionnaire. Date and cause of death were
determined from death certificates. Standardized mortality
ratios were calculated by the direct method. chi(2)-Square
test and Cox's proportional hazard analysis were used to
control for potential confounders. During a median follow-up
of 3.5 years (range 1 month to 4.6 years), 131 deaths
occurred. Of these, 29.8% were due to cardiopulmonary
disease (ICD 401-429), 13.0% due to cerebrovascular disease(
ICD 430-438), 13.0% due to acute diabetes metabolic
complications (250.1, 250.2), and 11.4% due to nephropathy (
580-589). Adjusted for age, people with NIDDM had 2.2 (95%
CI 1.6-2.9) times the risk of death than members of the
general population, and cause-specific standardized
mortality ratios were: CPD 4.6, nephropathy 8.8,
cerebrovascular disease 1.9, and neoplasm 0.7. Age, fasting
plasma glucose, hypertension, and proteinuria were
positively and independently associated with all-cause
mortality (P < 0.05 for each). Thus, NIDDM patients have
higher mortality rates than the general population in Taiwan
, and age, fasting plasma glucose, hypertension, and
proteinuria are associated with this excess risk. Proper
application of available interventions may control these
factors with a consequent reduction in mortality. Particular
attention is needed to prevent deaths from the acute
metabolic complications of diabetes. (C) 1999 Elsevier
Science Ireland Ltd. All rights reserved.
Subjects
diabetes
mortality
cardiopulmonary disease
Taiwan
SDGs
Type
journal article