Impact of non-alcoholic fatty pancreas disease on glucose metabolism
Journal
Journal of Diabetes Investigation
Journal Volume
8
Journal Issue
6
Pages
735-747
Date Issued
2017
Author(s)
Yu T.-Y.
Abstract
With the increasing global epidemic of obesity, the clinical importance of non-alcoholic fatty pancreas disease (NAFPD) has grown. Even though the pancreas might be more susceptible to ectopic fat deposition compared with the liver, NAFPD is rarely discussed because of the limitation of detection techniques. In the past, NAFPD was considered as an innocent condition or just part of clinical manifestations during the course of obesity. Recently, a growing body of research suggests that NAFPD might be associated with β-cell dysfunction, insulin resistance and inflammation, which possibly lead to the development of diabetes and metabolic syndrome. The present review summarized the current literature on the epidemiology, potential pathophysiology, diagnostic techniques, impact of NAFPD on β-cell function and insulin resistance, and the clinical relevance of the interplay between NAFPD and glucometabolic disorders. ? 2017 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd
Subjects
Diabetes mellitus; Metabolic syndrome; Non-alcoholic fatty pancreas disease
SDGs
Other Subjects
abdominal radiography; cell function; computer assisted tomography; diabetes mellitus; echography; endoscopic ultrasonography; glucose metabolism; human; insulin resistance; metabolic disorder; metabolic syndrome X; non alcoholic fatty pancreas disease; nonhuman; nuclear magnetic resonance imaging; nuclear magnetic resonance spectroscopy; pancreas disease; pancreas islet beta cell; pancreatic steatosis; pathophysiology; prevalence; priority journal; proton nuclear magnetic resonance; Review; steatosis; biological model; complication; metabolism; non insulin dependent diabetes mellitus; pancreas disease; pathology; physiology; glucose; Diabetes Mellitus, Type 2; Glucose; Humans; Insulin Resistance; Insulin-Secreting Cells; Models, Biological; Pancreatic Diseases
Publisher
Blackwell Publishing
Type
review