Three new clerodane diterpenes from polyalthia longifolia Var. Pendula
Journal
Molecules
Journal Volume
19
Journal Volume
19
Journal Issue
2
Journal Issue
2
Pages
2049-2060
Start Page
2049
End Page
2060
ISSN
14203049
Date Issued
2014-02
Author(s)
Wu, Tung-Ho
Cheng, Yung-Yi
Chen, Chao-Jung
Chou, Li-Chen
Huang, Li-Jiau
Chen, Yung-Husan
Kuo, Sheng-Chu
El-Shazly, Mohamed
Wu, Yang-Chang
Chang, Fang-Rong
Liaw, Chih-Chuang
Abstract
Three new clerodane diterpenes, (4→2)-abeo-cleroda-2,13E-dien-2,14- dioic acid (1), (4→2)-abeo-2,13-diformyl-cleroda-2,13E-dien-14-oic acid (2), and 16(R&S)- methoxycleroda-4(18),13-dien-15,16-olide (3), were isolated from the unripe fruit of Polyalthia longifolia var. pendula (Annonaceae) together with five known compounds (4-8). The structures of all isolates were determined by spectroscopic analysis. The anti-inflammatory activity of the isolates was evaluated by testing their inhibitory effect on NO production in LPS-stimulated RAW 264.7 macrophages. Among the isolated compounds, 16-hydroxycleroda-3,13-dien-15,16-olide (6) and 16-oxocleroda-3,13- dien-15-oic acid (7) showed promising NO inhibitory activity at 10 μg/mL, with 81.1% and 86.3%, inhibition, respectively.
Subjects
Annonaceae
Anti-inflammatory
Clerodane diterpenes
Pendula
Polyalthia longifolia var
SDGs
Type
journal article