The association between total serum isomers of per- and polyfluoroalkyl substances, lipid profiles, and the DNA oxidative/nitrative stress biomarkers in middle-aged Taiwanese adults
Journal
Environmental Research
Journal Volume
182
Pages
109064
Date Issued
2020
Author(s)
Abstract
Per- and polyfluoroalkyl substances (PFAS) have been widely used in consumer products. In vitro and animal studies have demonstrated that exposure to perfluorooctanoic acid (PFOA) and/or perfluorooctane sulfonate (PFOS) increases oxidative/nitrative stress. Recent studies have also found that isomers of PFOA/PFOS may have unique biological effects on clinical parameters. However, the correlation between PFOA/PFOS isomers and markers of oxidative/nitrative stress has never been investigated in the general population. In the current study, 597 adult subjects (ages between 22 and 63 years old) were enrolled from a control group of a case-control study entitled “Work-related risk factors and coronary heart disease”. We investigated the correlation between the serum isomers of PFOA/PFOS, lipid profiles, and the urine compounds 8-hydroxy-2-deoxyguanosine (8-OHdG) and 8-nitroguanine (8-NO2Gua) in these participants. There were 519 men and 78 women with a mean age of 45.8 years. Linear PFOA levels were positively correlated with serum low density lipoprotein cholesterol (LDL-C), small dense LDL, and triglyceride, and linear PFOS levels were positively correlated with LDL-C and HDL-C in multiple linear regression analyses. After controlling for potential confounders, the mean levels of 8-OHdG and 8-NO2Gua significantly increased across the quartiles of linear PFOS in multiple linear regression analyses. When both the 8-OHdG and 8-NO2Gua levels were above the 50th percentile, the odds ratio (OR) of higher levels of LDL-C (>75th percentile) with one unit increase in ln linear PFOS level was the highest (OR 3.15 (95% CI = 1.45–6.64), P = 0.003) in logistic regression models. In conclusion, serum linear PFOA/PFOS were correlated with lipid profiles, and linear PFOS was associated with urine oxidative/nitrative stress biomarkers. The positive correlation between linear PFOS and LDL-C was more marked when concentrations of urine oxidative/nitrative stress biomarkers were elevated. Further studies are needed to elucidate the causal relationships among PFAS isomers, lipid profiles, and oxidative/nitrative stress. ? 2019 Elsevier Inc.
Subjects
8-Hydroxy-2-deoxyguanosine (8-OHdG); 8-Nitroguanine (8-NO2Gua); Per- and polyfluoroalkyl substances (PFAS); Perfluorooctane sulfonate (PFOS); Perfluorooctanoic acid (PFOA)
SDGs
Other Subjects
8 hydroxydeoxyguanosine; 8 nitroguanine; biological marker; high density lipoprotein cholesterol; low density lipoprotein cholesterol; perfluoro 3,5 dimethylhexanoic acid; perfluoro 4,4 dimethylhexanoic acid; perfluoro 4,5 dimethylhexanoic acid; perfluoro 5 methylheptanoic acid; perfluoro 5,5 dimethylhexanoic acid; perfluoro 6 methylheptanoic acid; perfluoroalkanoic acid; perfluorooctanesulfonic acid; perfluorooctanoic acid; sodium per fluoro 1 methylheptanesulfonate; sodium perfluoro 3,5 dimethylhexanesulfonate; sodium perfluoro 4,4 dimethylhexanesulfonate; sodium perfluoro 4,5 dimethylhexanesulfonate; sodium perfluoro 5 methylheptanesulfonate; sodium perfluoro 5,5 dimethylhexanesulfonate; sodium perfluoro 6 methylheptanesulfonate; triacylglycerol; unclassified drug; alkanesulfonic acid; biological marker; DNA; fluorocarbon; lipid; octanoic acid derivative; adult; age structure; bioaccumulation; biochemical composition; biomarker; DNA; fluoride; lipid; oxidation; public health; serum; sulfonate; adult; Article; blood biochemistry; case control study; controlled study; female; high density lipoprotein cholesterol level; human; ischemic heart disease; isomer; lipid fingerprinting; low density lipoprotein cholesterol level; major clinical study; male; nitrative stress; oxidative stress; priority journal; risk factor; Taiwanese; triacylglycerol blood level; urine level; animal; blood; middle aged; young adult; Taiwan; Animalia; Adult; Alkanesulfonic Acids; Animals; Biomarkers; Caprylates; Case-Control Studies; DNA; Female; Fluorocarbons; Humans; Lipids; Male; Middle Aged; Oxidative Stress; Young Adult
Publisher
Academic Press Inc.
Type
journal article