Clinical applications of immunoglobulin G against different individual Aspergillus species for the diagnosis of chronic pulmonary aspergillosis among at-risk populations
Journal
Pathogens and global health
ISSN
2047-7732
Date Issued
2024-11-06
Author(s)
Lin, Chen-Chieh
Wu, Chang-Wei
Chen, Jung-Yueh
Abstract
-specific IgG is often used as a diagnostic test for chronic pulmonary aspergillosis (CPA), but few studies have evaluated the performance and serology of IgGs from species other than . In this study, we evaluated the serology and performance of different species-specific IgG antibodies in patients with CPA and at-risk populations and whether different species-specific IgGs could be of clinical utility and aid in the diagnosis of CPA caused by all . A total of 187 participants were included between 2020 and 2022 (12 with CPA, 75 with old tuberculosis [TB], 45 with active TB and 55 with bronchiectasis). We measured the serum , -specific, and mixed IgG levels (Phadia ImmunoCap). The correlation was the strongest between and (Spearman's rank: 0.940), followed by and (Spearman's rank: 0.915). -specific IgG was less strongly correlated with the other three species-specific IgG (Spearman's rank: 0.828-0.849). (4 of 6, 67%) was the dominant species. Using the at-least-one-positive approach, the highest performance was obtained when and IgGs were used (sensitivity, 0.75; specificity, 0.84). Significant cross-reactivity exists among different species IgGs although the correlation may be less significant for . In addition to the commonly used IgG test, IgGs specific to local prevalent species may provide additional clinical utility.
Subjects
Aspergillus IgG
Aspergillus flavus
Aspergillus fumigatus
Aspergillus niger
Aspergillus terreus
chronic pulmonary aspergillosis
SDGs
Type
journal article