氯乙烯工人世代生物標記研究(2/2)
Date Issued
2004-07-31
Date
2004-07-31
Author(s)
DOI
922320B002140
Abstract
The association between the
angiosarcoma of liver and vinyl chloride
monomer (VCM) exposure has been
established. Thus, VCM is classified as a
group I carcinogen by International
Agency for Research on Cancer (IARC).
Recently, the association between VCM
exposure and hepatocellular cancer is
also reported. However, the relationships
of VCM exposure with liver cirrhosis
and abnormal liver function are less
clear. Furthermore, hepatitis B infection
is common in Taiwan, which has been
reported to have synergistic effect with
chemicals including alcohol and
aflatoxin. In this study, we investigated
the dose response relationship between
VCM exposure and liver fibrosis (liver
fibrosis and cirrhosis). Then we further
tested the synergistic effects between
hepatitis virus infection and VCM
exposure on liver enzymes and liver
fibrosis. Furthermore, genetic
polymorphysims are also found to
modify the chemical induced liver
diseases. Here, we also examined the
effects of metabolic genotypes on VCM
related liver diseases.
A total of 568 male workers who
were employed in 5 polyvinyl chloride
(PVC) or 4 vinyl chloride monomer
(VCM) manufacturing factories were
included for analysis. Information
relating to current job title, alcohol
consumption and cigarette smoking was
obtained by an interviewer-administered
questionnaire. Exposure level of
chemical mixtures was classified by
hygienic effect (a summation of personal
time weighted average / reference
permissible exposure level of each
chemical) into high, moderate and low
exposure groups. Serum aspartate
aminotransferase (AST) and alanine
aminotransferase (ALT), hepatitis B
surface antigen (HBsAg), hepatitis B e
antigen (HBeAg), and anti-hepatitis C
antibody were assayed.
For studying the association
between VCM exposure and liver
fibrosis, a total of 347 workers with XRCC1 modified the relationship of
hepatitis virus infection related chronic
liver diseases.
We conclude that VCM may cause
abnormal liver function and chronic liver
diseases including liver fibrosis, liver
cirrhosis and splenomegaly. Further,
there was a synergistic effect between
hepatitis virus infection and VCM on
liver enzyme abnormality and possibly
for chronic liver diseases. Assessment of
fitness for work should be considered in
workers with hepatitis B and C infection,
when they have potential exposure to
hepatotoxin at workplace. Furthermore,
in countries where hepatitis B and C
virus infection is prevalent, more
stringent occupational standard is needed
to protect workers exposed to
hepatotoxin.
Subjects
Liver enzyme
liver fibrosis
liver cirrhosis
vinyl chloride
genetic
polymorphism
polymorphism
SDGs
Publisher
臺北市：國立臺灣大學公共衛生學院職業醫學與工業衛生研究所
Type
report
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