ILP-based pin-count aware design methodology for microfluidic biochips.
Journal
Proceedings - Design Automation Conference
Pages
258-263
Date Issued
2009
Author(s)
Lin, Cliff Chiung-Yu
Abstract
Digital microfluidic biochips have emerged as a popular alternative for laboratory experiments. To make the biochip feasible for practical applications, pin-count reduction is a key problem to higher-level integration of reactions on a biochip. Most previous works approach the problem by post-processing the placement and routing solutions to share compatible control signals; however, the quality of such sharing algorithms is inevitably limited by the placement and routing solutions. We present in this paper a comprehensive pin-constrained biochip design flow that addresses the pin-count issue at all design stages. The proposed flow consists of three major stages: (1) pin-count aware stage assignment that partitions the reactions in the given bioassay into execution stages, (2) pin-count aware device assignment that determines a specific device used for each reaction, and (3) guided placement, routing, and pin assignment that utilize the pin-count saving properties from the stage and device assignments to optimize the assay time and pin count. For both the stage and device assignments, exact ILP formulations and effective solution-space reduction schemes are proposed to minimize the assay time and pin count. Experimental results show the efficiency of our algorithms/flow and a 55-57% pin-count reduction over the state-of-the-art algorithms/flow. Copyright 2009 ACM.
Subjects
Biochip; Design methodology; Integer linear programming; Microfludics
Other Subjects
Computer aided design; Digital microfluidics; Integer programming; Design Methodology; Digital microfluidic biochips; Integer Linear Programming; Laboratory experiments; Micro fluidic biochips; Microfludics; Placement and routing; State-of-the-art algorithms; Biochips
Type
conference paper