Cholesterol-Lowering Effect of Phytosterol-Containing Lactic-Fermented Milk Powder in Hamsters
Resource
Food Chemistry, 119(3), 1121-1126
Journal
Food Chemistry
Pages
1121-1126
Date Issued
2010
Date
2010
Author(s)
Chien, Yung-Liang
Wu, Liang-Yi
Lee, Tsung-Cheng
Hwang, Lucy Sun
Abstract
Male hamsters were fed six different diets for 4 weeks. Group 1, fed with control diet of regular rodent chow. Group 2, fed with high-fat-high-cholesterol diet containing cholesterol and corn/coconut oil mixture. Group 3, the positive control fed with high-fat-high-cholesterol diet containing 0.74% (w/w) phytosterols. Groups 4-6 were the high-fat-high-cholesterol diet mixed with phytosterol-containing lactic-fermented milk powder (PSFMP) which contains 0.37%, 0.74% and 1.85% (w/w) of phytosterols, respectively. Results demonstrated that PSFMP could significantly decrease (P < 0.05-P < 0.001) the levels of total cholesterol (serum cholesterol), serum triacylglycerol, liver lipids and atherogenic index (LDL-C/HDL-C), while it could also significantly (P < 0.001) increase the level of fecal cholesterol. The pronounced hypolipidemic effects of PSFMP might be attributed to its ability to enhance cholesterol excretion. These results suggest that PSFMP could be used as a potential cholesterol-lowering ingredient in the management of hypercholesterolemia. © 2009 Elsevier Ltd. All rights reserved.
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