Is the inflammasome relevant for epithelial cell function?
Journal
Microbes and Infection
Journal Volume
18
Journal Issue
2
Pages
93-101
Date Issued
2016
Author(s)
Santana P.T.
Martel J.
Perfettini J.-L.
Kanellopoulos J.M.
Young J.D.
Coutinho-Silva R.
Ojcius D.M.
Abstract
Inflammasomes are intracellular protein complexes that sense microbial components and damage of infected cells. Following activation by molecules released by pathogens or injured cells, inflammasomes activate caspase-1, allowing secretion of the pro-inflammatory cytokines IL-1β and IL-18 from innate immune cells. Inflammasomes are also expressed in epithelial cells, where their function has attracted less attention. Nonetheless, depending on the tissue, epithelial inflammasomes can mediate inflammation, wound healing, and pain sensitivity. We review here recent findings on inflammasomes found in epithelial tissues, highlighting the importance of these protein complexes in the response of epithelial tissues to microbial infections.
SDGs
Type
short survey