Association of serum levels of 4-tertiary-octylphenol with cardiovascular risk factors and carotid intima-media thickness in adolescents and young adults
Journal
Environmental Pollution
Journal Volume
246
Pages
107-113
Date Issued
2019
Author(s)
Abstract
4-tertiary-Octylphenol levels were correlated with CVD risk factors and subclinical atherosclerosis in this cohort of adolescents and young adults. ? 2018 Elsevier LtdIn the family of alkylphenolic compounds, 4-tertiary-Octylphenol (4-t-OP) is extensively used in many products. In animal and in vitro studies, 4-t-OP exposure has been linked to cardiovascular disease (CVD) risk factors; however, there are no previous human epidemiological studies. In this study, 886 subjects were recruited from a cohort of Taiwanese adolescents and young adults to study the relationship between serum levels of 4-t-OP, CVD risk factors, and common carotid artery intima-media thickness (CIMT). The geometric mean (SD) 4-t-OP concentration was 32.52 (1.71) ng/mL. We found that serum levels of 4-t-OP were negatively associated with markers of glucose homeostasis (insulin, homeostasis model assessment of insulin resistance (HOMA-IR) and homeostasis model assessment of β-cell function (HOMA-β)), z score of body mass index (BMI z score) and CIMT but were positively associated with lipid profiles (high density lipoprotein cholesterol (HDL-C), Apolipoprotein A1). A one-unit elevation in natural log-transformed 4-t-OP (ng/mL) was negatively correlated with CIMT (mm) (β = ?0.029, SE = 0.003, P < 0.001) in multiple linear regression analyses. The relationship between 4-t-OP and CIMT remained the same in all subgroups or if bisphenol A (BPA) was considered a covariate. In this study, we observed that higher levels of 4-t-OP levels were negatively correlated with markers of glucose homeostasis, BMI z score, and CIMT; positively correlated with lipid profiles (HDL-C and apolipoprotein A) in this cohort. Future research on exposure to 4-t-OP and CVD risk factors is warranted. ? 2018 Elsevier Ltd
Other Subjects
Cardiology; Diseases; Glucose; Insulin; Linear regression; Lipoproteins; Phenols; 4-Tertiary-Octylphenol (4-t-OP); Bisphenol A; Cardio-vascular disease risk factors; Insulin resistance; Intima-media thickness; Risk assessment; 4 tert octylphenol; 4,4' isopropylidenediphenol; apolipoprotein A1; glucose; high density lipoprotein cholesterol; insulin; lipid; 4-tert-octylphenol; phenol derivative; adolescence; assessment method; cardiovascular disease; homeostasis; phenol; risk factor; serum; young population; adolescent; adult; arterial wall thickness; Article; blood level; body mass; cardiovascular risk; child; cohort analysis; concentration (parameter); controlled study; cross-sectional study; female; glucose homeostasis; homeostasis model assessment; human; male; pancreas islet beta cell; pancreas islet cell function; Taiwanese; blood; cardiovascular disease; pathophysiology; risk factor; Taiwan; young adult; Taiwan; Adolescent; Adult; Cardiovascular Diseases; Carotid Intima-Media Thickness; Cohort Studies; Female; Humans; Male; Phenols; Risk Factors; Taiwan; Young Adult
Publisher
Elsevier Ltd
Type
journal article