Post-transplant malignancy in liver transplantation: A single center experience
Journal
Medicine (United States)
Journal Volume
93
Journal Issue
28
Pages
e310
Date Issued
2014
Abstract
We aim to determine the incidence of malignancy after liver transplantation (LT) compared to general population.The records of patients who received LTs at our center from October 1989 and November 2012 were retrospectively reviewed. The standardized incidence ratio (SIR) of cancer in the patients was compared to general population using the data from the Taiwan Cancer Registry. Survival was estimated using the Kaplan-Meier method.A total of 444 patients were included. Malignancy was found in 46 (28 de novo and 19 recurrent malignancies) patients (10.4%) with the median follow up of 4.2 ± 4.2 years. The median time of cancer occurrence after transplant was 1.2 ± 1.9 years (range, 0.2-9.1 years). Post-transplant lymphoproliferative disorder was the most frequent de novo malignancy (57.1% [16/28]). The cumulative incidence rates of all malignancies were 5.1%, 10.4%, 12.8%, 15.8%, and 15.8% at 1, 3, 5, 10, and 15 years, respectively. The cumulative incidence rates of de novo malignancies were 3.4%, 5.97%, 7.7%, 10.9%, and 10.9 % at 1, 3, 5, 10, and 15 years. Compared to general population, transplant recipients had significantly higher incidence of all de novo cancers (SIR: 3.26, 95% confidence interval [CI]: 2.17-4.72), hematologic (SIR: 58.4; 95% CI, 33.3-94.8), and bladder (SIR: 10.2, 95% CI: 1.1-36.7) cancers. The estimated mean survivals after transplantation in cancer-free, de novo cancer, and recurrent cancer patients were 17.7 ± 0.5, 11.3 ± 1.2, and 3.6 ± 0.6 years, respectively.There is a significantly increased risk of malignancies after LT in the Taiwanese population. Copyright ? 2014 Wolters Kluwer Health / Lippincott Williams & Wilkins.
SDGs
Other Subjects
adolescent; adult; aged; Article; bile duct carcinoma; bladder cancer; bone cancer; brain cancer; breast cancer; cancer incidence; cancer mortality; cancer recurrence; cancer risk; cancer survival; cause of death; child; controlled study; female; follow up; gallbladder cancer; hemangioendothelioma; human; infant; Kaposi sarcoma; liver cell carcinoma; liver transplantation; lung cancer; lymphoepithelioma; major clinical study; male; malignant neoplastic disease; middle aged; myelodysplastic syndrome; pancreas cancer; postoperative complication; postoperative infection; posttransplant lymphoproliferative disease; posttransplant malignancy; retrospective study; salivary gland cancer; skin cancer; standardized incidence ratio; Taiwanese; thyroid cancer; thyroid papillary carcinoma; transitional cell carcinoma; incidence; Kaplan Meier method; liver transplantation; Neoplasms; Postoperative Complications; preschool child; prognosis; risk factor; survival rate; Taiwan; trends; young adult; Adolescent; Adult; Aged; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Incidence; Infant; Kaplan-Meier Estimate; Liver Transplantation; Male; Middle Aged; Neoplasms; Postoperative Complications; Prognosis; Retrospective Studies; Risk Factors; Survival Rate; Taiwan; Young Adult
Publisher
Lippincott Williams and Wilkins
Type
journal article