Colostrum’s Immunomodulatory Activities and Inhibitory Effects on Human Leukemic U937 Cells
Date Issued
2006
Date
2006
Author(s)
Kung, Hua-Ting
DOI
zh-TW
Abstract
Colostrum is breast milk produced after giving birth and lasts for 2-4 days. Bovine colostrum contains essential nutrients, growth factors, antimicrobial compounds and immune-regulating constituents either not present in milk or present in substantially lower concentrations. Colostrum is thought to protect neonates from infection, as well as to facilitate the immune maturation. In this study the immunomodulatory activities and anti-proliferation effect of human lukemic cell U937 were being invested. Results suggested that colostrum collected on day 1 and 2 after onset of lactation enhanced the growth of peripheral blood mononuclear cells (MNCs) in a dose dependent manner and significantly increased the population of T cell、Tc cell and NK cell. Moreover, day 1 to day 4 colostrums were capable to induce MNCs to secrete IL-1β, IFN-γ and TNF-α, which subsequently inhibited the growth of U937 cells and further induced it’s differentiation into mature monocytes or macrophages.
Lactoferrin is the most prominent immunomodulatory factor within colostrum. It has been proven that lactoferrin is at its maximum in the colostrum obtained at parturition and gradually decrease with time course of lactation. The present investigation demonstrated that lactoferrin, even at very low concentration, could enhance the growth of PBMC. However, its effect on growth inhibition of U937 was not significant. In addition, when colostrum was fractionated by acid precipitation, the MNC growth effect was found in the precipitated fraction containing lactoferrin.
Subjects
初乳
人類白血病細胞
Colostrum
Human Leukemic U937 Cells
Type
thesis
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