Targeted delivery of hyaluronan-immobilized magnetic ceramic nanocrystals
Journal
Journal of Biomedical Nanotechnology
Journal Volume
12
Journal Issue
1
Pages
103-113
Date Issued
2016
Author(s)
Abstract
Effective cancer therapy relies on delivering the therapeutic agent precisely to the target site to improve the treatment outcome and to minimize side effects. Although surgery, chemotherapy, and radiotherapy are the standard methods commonly used in clinics, hyperthermia has been developed as a new and promising strategy for cancer therapy. In this study, magnetic bioceramic hydroxyapatite (mHAP) nanocrystals have been developed as heat mediator for intracellular hyperthermia. Hyaluronic acid (HA) modified mHAP nanocrystals are synthesized by a wet chemical precipitation process to achieve active targeting. The results demonstrate that the HA targeting moiety conjugated by a poly(ethylene glycol) (PEG) spacer arm is successfully immobilized on the surface of mHAP The HA-modified mHAP possesses relatively good biocompatibility, an adequate biodegradation rate and superparamagnetic properties. The HA-modified mHAP could be localized and internalized into HA receptor-overexpressed malignant cells (e.g., MDA-MB-231 cell) and used as the heat generating agent for intracellular hyperthermia. The results from this study indicate that biocompatible HA-modified mHAP shows promise as a novel heat mediator and a specific targeting nanoagent for intracellular hyperthermia cancer therapy. Copyright ? 2016 American Scientific Publishers All rights reserved.
SDGs
Other Subjects
Bioceramics; Biocompatibility; Biodegradation; Chemotherapy; Diseases; Hyperthermia therapy; Magnetism; Nanocrystals; Nanomagnetics; Nanoparticles; Oncology; Polyethylene glycols; Precipitation (chemical); Biocompatible; Biodegradation rate; Cancer-targeting; Hyperthermia; Hyperthermia cancer therapies; Magnetic nano-particles; Superparamagnetic property; Wet-chemical precipitation; Hyaluronic acid; caspase 3; caspase 7; hyaluronic acid; hydroxyapatite; iron; lactate dehydrogenase; macrogol; nanocrystal; hyaluronic acid; magnetite nanoparticle; nanocapsule; Article; biocompatibility; biodegradation; cancer therapy; chromatin condensation; dispersion; human; human cell; hyperthermic therapy; in vitro study; infrared spectroscopy; mass spectrometry; physical chemistry; precipitation; temperature; transmission electron microscopy; zeta potential; adsorption; animal; ceramics; chemistry; molecularly targeted therapy; mouse; Neoplasms, Experimental; pathology; procedures; thermotherapy; treatment outcome; tumor cell line; ultrastructure; Adsorption; Animals; Cell Line, Tumor; Ceramics; Hyaluronic Acid; Hyperthermia, Induced; Magnetite Nanoparticles; Mice; Molecular Targeted Therapy; Nanocapsules; Neoplasms, Experimental; Treatment Outcome
Publisher
American Scientific Publishers
Type
journal article