The involvement of epididymal secretory proteins in the selection processes of sperm cells
Journal
Molecular Reproduction and Development
Journal Volume
83
Journal Issue
3
Pages
187-187
Date Issued
2016
Author(s)
Abstract
VISIONS: the art of scienceThe epididymis is the primary site for sperm maturation and storage.Fully differentiated testicular sperm reside in convoluted epididymal tubule, constantly interacting with the epididymal epithelium and their secretions.Epididymal secretions contain a large pool of proteins and molecules that can modify the sperm membrane surface.Quiescin Q6 sulfhydryl oxidase 2 (QSOX2), an epididymal-and seminal vesicle-enriched secre-tory protein, catalyzes the oxida-tion of thiol group into stable disulfi de bonds.This enzyme affects protein folding and modi-fi es the compositions of the extracellular matrix.Detailed analysis of QSOX2 function indicates that it participates in the preejaculate selection of sperm cells by regulating sperm aggregation and tyrosine phosphorylation.
SDGs
Type
journal article