Stereoselective synthesis of Neu5Acα(2→5)Neu5Gc: The building block of oligo/poly(→5-OglycolylNeu5Gcα2→) chains in sea urchin egg cell surface glycoprotein
Journal
Journal of Organic Chemistry
Journal Volume
67
Journal Issue
21
Pages
7565-7568
Date Issued
2002
Author(s)
Abstract
The synthesis of a sialic acid dimer derivative, Neu5Acalpha(2-->5)Neu5Gc, is described. The synthetic strategy is based on the use of allyl alcohol to achieve an exclusive alpha-sialylation product. The allyloxy group is also a latent glycolic acid that provides the subsequent coupling with neuraminate with minimal protection-deprotection manipulations.
SDGs
Type
journal article