Tensins - emerging insights into their domain functions, biological roles and disease relevance
Journal
Journal of cell science
Journal Volume
134
Journal Issue
4
Pages
Article number jcs254029
Date Issued
2021-02-17
Author(s)
Lo, Su Hao
Abstract
© 2021. Published by The Company of Biologists Ltd. Tensins are a family of focal adhesion proteins consisting of four members in mammals (TNS1, TNS2, TNS3 and TNS4). Their multiple domains and activities contribute to the molecular linkage between the extracellular matrix and cytoskeletal networks, as well as mediating signal transduction pathways, leading to a variety of physiological processes, including cell proliferation, attachment, migration and mechanical sensing in a cell. Tensins are required for maintaining normal tissue structures and functions, especially in the kidney and heart, as well as in muscle regeneration, in animals. This Review discusses our current understanding of the domain functions and biological roles of tensins in cells and mice, as well as highlighting their relevance to human diseases.
Subjects
Cancer | CTEN | Cystic kidney | Focal adhesion | Mitral valve prolapse | Nephrotic syndrome | PTB | SH2 | Tensin
SDGs
Other Subjects
actin; focal adhesion kinase; phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase; protein SH2; protein tyrosine phosphatase; tensin; tensin; Tns2 protein, mouse; amino acid sequence; binding site; cell adhesion; cell invasion; cell migration; cell proliferation; chronic obstructive lung disease; cytoskeleton; disease association; epithelial mesenchymal transition; extracellular matrix; genome-wide association study; mitral valve prolapse; nuclear localization signal; pancreas cancer; protein domain; protein function; protein protein interaction; protein structure; Review; signal transduction; animal; focal adhesion; metabolism; mouse; signal transduction; Animals; Cell Adhesion; Cell Proliferation; Focal Adhesions; Mice; Signal Transduction; Tensins
Publisher
Company of Biologists Ltd
Type
review