Secretome from estrogen-responding human placenta-derived mesenchymal stem cells rescues ovarian function and circadian rhythm in mice with cyclophosphamide-induced primary ovarian insufficiency
Journal
Journal of biomedical science
Journal Volume
31
Journal Issue
1
Start Page
95
ISSN
1021-7770
Date Issued
2024-12
Author(s)
Le, Duy-Cuong
Ngo, Mai-Huong T
Kuo, Yung-Che
Chen, Shu-Hwa
Lin, Chung-Yen
Pham, Quoc Thao Trang
Au, Heng-Kien
Myung, Jihwan
Huang, Yen-Hua
Abstract
This study is the first to demonstrate that, in considering the estrogen niche in ovarian tissue, an estrogen-priming ER+pcMSC secretome achieved ovarian regeneration and restored the circadian rhythm in a CTX-induced POI mouse model. The potential factors involved include angiogenin and exosomal miRNAs in the ER+pcMSC secretome. These findings offer insights into potential stem cell therapies for chemotherapy-induced POI and circadian rhythm disruption.
Subjects
Angiogenin
Estrogen receptor
Exosomal miRNA
Ovarian circadian rhythm disorder
Placenta mesenchymal stem cell
Primary ovarian insufficiency
Type
journal article