High frequency of heat shock protein 27 overexpression is a highly effective, high-coverage marker for minimal residual disease detection in children with B-cell acute lymphoblastic leukemia
Journal
Pediatric blood & cancer
Journal Volume
70
Journal Issue
1
Date Issued
2023-01
Author(s)
Su, Ying-Hui
Lin, Dong-Tsamn
Lin, Kai-Hsin
Coustan-Smith, Elaine
Abstract
Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer. Minimal residual disease (MRD) detection is the most powerful prognostic tool for monitoring treatment efficacy and predicting clinical outcomes. We aimed to identify key leukemia-associated markers, the proportions of differential expression in patients, and the most effective marker combination for MRD detection by flow cytometry.
Subjects
acute lymphoblastic leukemia; flow cytometry; leukemia-associated markers; minimal residual disease; pediatrics
SDGs
Publisher
WILEY
Type
journal article