Programmable On-Demand Drug Release Device：An Electro-stimulated Approach
Date Issued
2012
Date
2012
Author(s)
Yi, Yen-Tsai
Abstract
Drug therapy efficacy depends on therapeutic concentrations of drugs at disease sites. An ideal controlled drug delivery device should safely contain a large quantity of drugs, release little or no drug in the “off ” state, be repeatedly switchable to the “on” state without mechanically disrupting the device, and can actively control release rates. In this thesis, an electro-stimulated membrane-based drug delivery device was developed to release drugs on demand. Drugs over a broad range of molecular weights (300-40000 Da) and different charge properties can be delivered by the same drug delivery approach. Ionic drug molecules were electrically ejected from polyelectrolyte hydrogels into bulk solution in vitro, the response time between electric stimulus and release amounts was fast, and without mechanically disrupting the membrane-based drug delivery device .We showed that the dose of drug delivered across drug delivery device could be tuned by different material of membrane, the strength of applied voltage, and the waveform of applied voltage, allowing for pulsatile drug delivery system of model drug, we could control the release rate at 1 order of magnitude (100~1000 ng / hr) during release processes. The system reported here has great potential for use in biomaterials, tissue engineering, implant technology, and biosensors for biomedical applications.
Subjects
electro-stimulated
membrane-based
pulsatile drug delivery
ionic drug molecules
material of membrane
Type
thesis
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