利用血清學來尋找人類肝細胞癌的腫瘤抗原
Other Title
Serological Identification of Tumor Antigens
in Human Hepatocellular Carcinoma
in Human Hepatocellular Carcinoma
Date Issued
2000
Date
2000
Author(s)
陳健弘
DOI
892315B002024
Abstract
Identification of tumor-specific antigens
is the prelude for antigen-specific immunotherapy. Recently, a novel strategy,
serological analysis of recombinant cDNA
expression library (SEREX), has been
successfully used to identify novel tumor-specific
antigens. Thus, we tried to apply the
SEREX method to identify tumor antigens in
human hepatocellular carcinoma (HCC).
However, this work has not been completely
yet because of some techniques problems in
constructing a good cDNA library. We are
still trying to fix this problem.
Meanwhile, we investigate the cancer-testis
antigens expressions in human HCCs. In
the 30 HCCs studied, SSX-1,-2,-4,-5, SCP-1,
and NY-ESO-1 mRNA expressions were
detected in 24 (80%), 14 (46.7%), 22
(73.3%), 10 (33.3%), 2 (6.7%), and 11
(36.7%), respectively. Expressions of these
genes were detected in few non-tumor liver
tissues. The cancer-testis antigens are
e x p r e s s e d i n a h i g h p e r c e n t a g e o f
hepatocellular carcinomas. These cancer-testis
antigen genes products are potential
targets for antigen-specific immunotherapy of
HCC.
Subjects
tumor antigens
hepatocellular carcinoma
cancer-testis
antigen
antigen
immunotherapy
SDGs
Publisher
臺北市：國立臺灣大學醫學院內科
Type
report
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