Intravascular Large B cell Lymphoma in Taiwan: An Asian Variant of Non-germinal-center Origin
Journal
Journal of the Formosan Medical Association
Journal Volume
109
Journal Issue
3
Pages
185-191
Date Issued
2010
Author(s)
Abstract
Background/Purpose: Intravascular large B cell lymphoma (IVLBCL) is a rare variant of diffuse large B cell lymphoma. We reported the clinical and immunohistochemical characteristics of 10 cases of IVLBCL from Taiwan between 1995 and 2008. Methods: Clinical data were reviewed and immunoperoxidase stains were performed with antibodies against CD20, CD10, Bcl-6, MUM1, and CD5. Results: There were eight males and two females with a median age of 59 years. Patients presented with dyspnea (5/10), fever (7/10), splenomegaly (5/10), and bone marrow involvement (8/10). Anemia (9/10), thrombocytopenia (6/10), and elevated serum lactate dehydrogenase or ferritin levels (8/10) were also common. Nine cases were CD20+CD10-Bcl-6-, similar to non-germinal center B cells. Six out of seven patients survived after chemotherapy, but three cases with thrombocytopenia that precluded chemotherapy died within 2 months. Conclusion: Our cases of IVLBCL had a non-germinal center B origin and belonged to the Asian variant of this disease. The liver, spleen, and bone marrow, but rarely the skin or brain, were involved. Thrombocytopenia is a major risk factor for mortality in these cases. ? 2010 Formosan Medical Association & Elsevier.
SDGs
Other Subjects
CD20 antigen; CD5 antigen; common acute lymphoblastic leukemia antigen; ferritin; interferon regulatory factor 4; lactate dehydrogenase; protein bcl 6; adult; aged; anemia; article; B cell lymphoma; cancer diagnosis; cancer localization; cancer mortality; clinical article; clinical examination; dyspnea; female; ferritin blood level; fever; human; human tissue; immunohistochemistry; immunoperoxidase staining; lactate dehydrogenase blood level; male; risk factor; splenomegaly; Taiwan; thrombocytopenia; vascular tumor; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Asian Continental Ancestry Group; Female; Humans; Immunohistochemistry; Lymphoma, B-Cell; Male; Middle Aged; Survival Analysis; Taiwan; Thrombocytopenia; Treatment Outcome; Tumor Markers, Biological; Vascular Neoplasms
Type
journal article