Lymphocyte Antigen 6 Complex, Locus C+ Monocytes and Kupffer Cells Orchestrate Liver Immune Responses Against Hepatitis B Virus in Mice
Journal
Hepatology
Journal Volume
69
Journal Issue
6
Pages
2364-2380
Date Issued
2019
Author(s)
Wu, Li-Ling
Peng, Wei-Hao
Wu, Hui-Lin
Liao, Pei-Hsuan
Lin, Jing-Shan
Chen, Yan-Rong
Hong, Yen-Tien
Abstract
monocytes and KCs may, respectively, represent the resistance and tolerance arms of host defenses. These two cell types play an essential role in determining HBV clearance/tolerance. Manipulation of these cells is a promising avenue for immunotherapy of HBV-related liver diseases.
SDGs
Other Subjects
alanine aminotransferase; caspase 3; chemokine receptor CCR2 antagonist; clodronic acid; gamma interferon; interleukin 10; liposome; lymphocyte antigen; lymphocyte antigen 6 complex locus c; lymphotoxin; monocyte chemotactic protein 1; transcription factor 3; tumor necrosis factor; unclassified drug; virus antigen; chemokine; cytokine; hepatitis B core antigen; hepatitis B surface antigen; antigen specificity; Article; CD8+ T lymphocyte; cell population; controlled study; cytokine production; genetic transfection; Hepatitis B virus; immune response; immunofluorescence; Kupffer cell; liver; male; monocyte; mouse; nonhuman; priority journal; protein expression; transmission electron microscopy; viral clearance; animal; blood; C3H mouse; cell culture; disease model; genetics; hepatitis B; Hepatitis B virus; human; immunology; immunotherapy; Kupffer cell; liver cell; metabolism; monocyte; pathophysiology; procedures; randomization; reference value; Animals; CD8-Positive T-Lymphocytes; Cells, Cultured; Chemokines; Cytokines; Disease Models, Animal; Hepatitis B; Hepatitis B Core Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatocytes; Humans; Immunotherapy; Kupffer Cells; Male; Mice; Mice, Inbred C3H; Monocytes; Random Allocation; Reference Values; Transfection
Publisher
John Wiley and Sons Inc.
Type
journal article