The effects of the purified thrombin-like and anticoagulant principles of Agkistrodon acutus venom on blood coagulation in vivo
Journal
Toxicon
Journal Volume
14
Journal Issue
1
Pages
49-54
Date Issued
1976
Author(s)
Abstract
The effects of the purified thrombin-like and anticoagulant principles of the snake venom of Agkistrodon acutus on blood coagulation of rabbits in vivo were studied. The thrombin-like principle caused a marked prolongations of whole blood coagulation time and one-stage plasma prothrombin time and a marked decrease of the fibrinogen concentration, while no significant change in the two-stage plasma prothrombin level was detected. It is concluded that the retardation of blood clotting by the thrombin-like principle was chiefly due to the decrease of plasma fibrinogen level. The anticoagulant principle caused a marked, but transient prolongation of whole blood coagulation time and one-stage plasma prothrombin time with no significant change in the two-stage plasma prothrombin level or plasma fibrinogen level. Combining these results with our previous in vitro findings, it is concluded that the retardation of blood clotting by the anticoagulant principle might be due to the interference in the interaction between prothrombin and its activation factors. © 1976.
SDGs
Type
journal article