Surface conjugation of anti-fouling polymers via pyrogallol-based chemistry

Abstract

Statement of Purpose: Surface modification for anti-fouling purpose is important for some biomedical devices. However, many methods for conjugation of anti-fouling materials are substrate-dependent. We developed a simple one-step coating method for surface immobilization of sulfobetaine methacrylate (SBMA) or poly-(ethylene glycol) (PEG) via deposition of self-polymerized pyrogallol (PG). The anti-fouling polymers were successfully anchored on various substrates when the SBMA conjugation of monomers containing amine groups or PEG tailing with aldehyde groups. The modified surfaces exhibited excellent resistance to fibroblast cells and proteins. Controlling the coating for an array of incubation time, we investigated through the surface properties corresponding to anti-fouling behaviors of biomolecules. The high transparency of the coating allow this strategy applied on the development of new generation medical devices. ? 2019 Omnipress - All rights reserved.