Circulating mitochondrial cell-free DNA dynamics in patients with mycobacterial pulmonary infections: Potential for a novel biomarker of disease
Journal
Frontiers in immunology
Journal Volume
13
Pages
1040947
Date Issued
2022
Author(s)
Pan, Sheng-Wei
Syed, Rehan R
Catanzaro, Donald G
Ho, Mei-Lin
Tsai, Tsung-Yeh
Tseng, Yen-Han
Feng, Jia-Yih
Chen, Yuh-Min
Su, Wei-Juin
Catanzaro, Antonino
Rodwell, Timothy C
Abstract
Human mitochondrial cell-free DNA (Mt-cfDNA) may serve as a useful biomarker for infectious processes. We investigated Mt-cfDNA dynamics in patients with pulmonary mycobacterial infections to determine if this novel biomarker could be used to differentiate disease states and severity.
Subjects
biomarker; cell-free DNA; mitochondria; pulmonary tuberculosis; treatment response monitoring
Type
journal article