RELATIONSHIP OF HEPATITIS B VIRUS INFECTION TO HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 INFECTION
Resource
JOURNAL OF INFECTIOUS DISEASES v.167 n.2 pp.299-304
Journal
JOURNAL OF INFECTIOUS DISEASES
Journal Volume
v.167
Journal Issue
n.2
Pages
299-304
Date Issued
1993
Date
1993
Author(s)
TWU, SHIING-JER
ROGER, DETELS
KENRAD, NELSON
BARBARA, R., VISSCHER
RICHARD, KASLOW
JOHN, PALENICEK
Abstract
The Multicenter AIDS Cohort Study (MACS) was designed to study the natural history of human immunodeficiency virus type 1 (HIV-1) infection, including the relationship between hepatitis B virus (HBV) and HIV-1 infection. In total, 4954 homosexual men were recruited from April 1984 through March 1985 and have been followed up thereafter every 6 months. Hepatitis B surface antigen and hepatitis B core antibody were tested for at the first visit by RIA or EIA; HIV-1 antibody testing was done at each visit by ELISA and confirmed by Western blot assay. The role of HBV infection in HIV-1 seroconversion was studied by stratification for sexual behavior and disease visit by visit. The adjusted risk ratio was 2.02 for hepatitis B surface antigen carriers and 2.14 for hepatitis-immune cases compared with hepatitis -susceptible subjects. Similar results were obtained using a logistic regression model. After taking into account changes in sexual behavior and disease over time, the authors conclude that past HBV infection remains suspect as a cofactor or as a surrogate for other factors associated with HIV-1 seroconversion. #B0193002
Subjects
Ｂ型肝炎病毒
愛滋病毒
血清陽轉
愛滋病毒感染
HEPATITIS VIRUS
HUMAN IMMUNODEFICIENCY VIRUS
SEROCONVERSION
HIV INFECTION
SDGs
Type
journal article