The Study of Association between Esophageal Cancer and the Genetic Polymorphism in Carcinogen-metabolic Enzyme
Date Issued
2000-07-31
Date
2000-07-31
Author(s)
李章銘
Advisor
國立臺灣大學醫學院外科
DOI
892314B002189
Abstract
The interaction between the environmental toxins and the polymorphic xenobiotic
metabolizing enzymes can determine the individual susceptibility to chemical carcinogenesis.
Objective: In this study, we investigated the association of the genetic polymorphisms of
phase I (CYP1A1, CYP2E1) and phase II (GSTM1 and GSTT1) xenobiotic metabolizing
enzymes with the risk of esophageal cancer in Taiwan. Method: We recruited 105 cases of
esophageal squamous cell carcinoma and 266 persons of healthy controls during 1996-1999 in
Taiwan. The genotypes of the genobiotic metabolizing enzymes were determined by PCR (for
CYP1A1 and CYP2E1) or PCR-RFLP (for GSTM1 and GSTM1). Results: There was no
significant difference in distribution of the genotypes of CYP1A1, CYP2E1, GSTM1 or GSTT1
between the patients and controls. However, multivariate analysis in the cigarette smokers
showed that GSTT1 absent genotype significantly increased the risk of esophageal cancer,
with an OR (95% CI) of 2.44 (1.17-5.08). Cigarette smokers with variant allele of CYP1A1
also had a marginal increase of risk to develop esophageal cancer as compared to the wild
CYP1A1 genotype (OR = 1.70; 95% CI= 0.99-2.94). In contrast to the results found in
cigarette smokers, the GSTT1 absent genotype was less frequent in patients of esophageal
squamous cell carcinoma with an OR of 0.29 (95% CI=0.11-0.73). Conclusion: Our results
revealed that the GSTT1 and CYP 1A1 genetic polymorphism might interact with cigarette
smoke to modulate the risk of esophageal cancer in Taiwan.
Subjects
食道癌
基因多型性
SDGs
Publisher
臺北市：國立臺灣大學醫學院外科
Type
report
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