Aggregation inhibitory activity of minor acetophenones from Paeonia species
Journal
Planta Medica
Journal Volume
65
Journal Issue
7
Pages
595-599
Date Issued
1999
Author(s)
CHE-MING TENG
Abstract
Two minor acetophenones, 2,5-dihydroxy-4-methoxy-acetophenone (2) and 2,5-dihydroxy-4-methylacetophenone (7) from Paeonia species were found to selectively inhibit the aggregation of rabbit platelets induced by arachidonic acid. They were more potent than the major compound, paeonol (1), and 7 also inhibited the formation of TXA2 and PGD2 from arachidonic acid.
Type
journal article