Improvement of juvenile dermatomyositis with calcinosis universalis after treatment with intravenous immunoglobulin
Journal
International Journal of Rheumatic Diseases
Journal Volume
11
Journal Issue
1
Pages
77-80
Date Issued
2008
Author(s)
Abstract
Juvenile dermatomyositis is a chronic multisystemic disease. It is believed to be of autoimmune aetiology and is characterized by the presence of vasculitis affecting striated muscle and skin. Calcinosis occurs in about 40% of cases. We report a case of a 10-year-old girl diagnosed with juvenile dermatomyositis who presented with difficulty in walking and inability to completely extend the four extremities due to calcinosis universalis. Calcinosis had progressed despite a 3-year administration of diltiazem, hydroxychloroquine, aluminium hydroxide, cyclosporin, and probenecid. The introduction of monthly intravenous immunoglobulin therapy for 15 months lessened disease activity, and markedly regressed calcinosis, and improved functional outcome. ? 2008 Asia Pacific League of Associations for Rheumatology.
SDGs
Other Subjects
aluminum hydroxide; cyclosporin; diltiazem; hydroxychloroquine; immunoglobulin; methotrexate; methylprednisolone; prednisolone; probenecid; anamnesis; article; calcinosis; calcinosis universalis; case report; clinical protocol; dermatomyositis; disease activity; disease course; drug pulse therapy; female; follow up; human; human tissue; juvenile dermatomyositis; low drug dose; muscle biopsy; myopathy; priority journal; school child; scoring system; soft tissue calcification; walking difficulty
Type
journal article