Combining Transmission-Nontransmission Information and Genes Identical by Descent Information for Test of Linkage in Affected Sibs (II): A Minimum Combined Variance Method
Date Issued
2005
Date
2005
Author(s)
Chen, Shiu-Kuei
DOI
zh-TW
Abstract
The transmission/disequilibrium test (TDT) and mean test are the two nonparametric methods for test of linkage for affected sib pairs data. The TDT tests the equality of the probability of a marker allele transmitted or not transmitted with the disease gene, and the mean test tests whether the observed number of marker identical by descent in affected sibs is equal to the expected. The mean test and TDT have different performances in power. The power of mean test is higher than that of TDT when the linkage disequilibrium is weak, but, in contrast, the power of TDT is higher than that of mean test when linkage disequilibrium is strong. In this paper we proposed a minimum variance combining method to combine the two sources of information from the TDT aspect and the mean test aspect. We derived the combining weights for the two test statistics. Simulation studies of the powers of TDT, mean test and the new statistic in various genetic models were conducted.
Subjects
染病同胞對
傳遞不平衡檢定
均值檢定
同源全等基因數目
連鎖不平衡
IBD
TDT
mean test
affected sibs
linkage disequilibrium
Type
thesis
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