Recovering the mechanical properties of denatured intervertebral discs through Platelet-Rich Plasma therapy
Journal
Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Journal Volume
2015-November
Pages
933-936
Date Issued
2015
Author(s)
Khalaf, K.
Nikkhoo, M.
Kuo, Y.-W.
Hsu, Y.-C.
Parnianpour, M.
Campbell-Kyureghyan, N.
Haghpanahi, M.
Wang, J.-L.
Abstract
Degenerative disc disease is one of the most common causes of low back pain instigating huge socioeconomic costs and posing an immense burden on healthcare systems worldwide. New therapeutic approaches to damaged intervertebral discs are therefore of great interest. Platelet-Rich Plasma (PRP) has been proposed for the repair and regeneration of degenerated discs, but there remains a knowledge gap regarding its effectiveness and influence on disc material properties. The objective of this study was to investigate and quantify the material properties of intact, denatured, and PRP treated discs. A systematic methodology was established in the process, where ex-vivo experiments were conducted and material properties were extracted using an inverse finite element approach. The results showed that PRP is able to recover the mechanical properties of denatured discs, thereby providing a promising effective therapeutic modality. ? 2015 IEEE.
SDGs
Other Subjects
human; intervertebral disk; intervertebral disk degeneration; low back pain; regeneration; thrombocyte rich plasma; Humans; Intervertebral Disc; Intervertebral Disc Degeneration; Low Back Pain; Platelet-Rich Plasma; Regeneration
Type
conference paper