Models of microbiome evolution incorporating host and microbial selection
Journal
Microbiome
Journal Volume
5
Journal Issue
1
Date Issued
2017
Author(s)
Abstract
Numerous empirical studies suggest that hosts and microbes exert reciprocal selective effects on their ecological partners. Nonetheless, we still lack an explicit framework to model the dynamics of both hosts and microbes under selection. In a previous study, we developed an agent-based forward-time computational framework to simulate the neutral evolution of host-associated microbial communities in a constant-sized, unstructured population of hosts. These neutral models allowed offspring to sample microbes randomly from parents and/or from the environment. Additionally, the environmental pool of available microbes was constituted by fixed and persistent microbial OTUs and by contributions from host individuals in the preceding generation.
Subjects
Commensal and pathogen; Diversity; Microbiome; Selection
Publisher
Springer Science and Business Media {LLC}
Type
journal article
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Name
Models of microbiome evolution incorporating host and microbial selection
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2.14 MB
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