Analysis of Radiation-Induced Liver Disease Using the Parallel Architecture NTCP Model
Date Issued
2004
Date
2004
Author(s)
Liu, Hua-Shan
DOI
zh-TW
Abstract
An optimized treatment plan procedure of radiation therapy (RT) is done by delivering a sufficient dose of radiation to eradicate cancerous cells without having severe complication in healthy organs. For this reason, radiobiological models should be introduced to quantify the radiobiological response of normal tissues to radiotherapy. To predict the incidence of radiation-induced disease in parallel organs, the parallel architecture normal tissue complication probability (NTCP) model hypothesizes that a complication would be caused if the damaged fraction of the organ volume (f) exceeds the threshold of a critical one, ft (the “ functional reserve”). This study analyzed data of normal liver function from 4 patient subgroups with the parallel NTCP model to investigate the tolerance of the partial liver irradiation by evaluating the value of f. The calculated f from maximum likelihood estimated (MLE) parameters shows that cases of radiation-induced liver disease (RILD) have been reported in patients with a value of f larger than 0.4.
Subjects
生物機率模型
平行性器官
parallel architecture
NTCP model
SDGs
Type
thesis
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