Alkanethiols on Gold-coated Micro-cantilever:Absorption Characterization and Deflection Measurement
Date Issued
2009
Date
2009
Author(s)
Chang, Tzu-Hsuan
Abstract
The microcantilever sensor is one of the most promising platforms for the next-generation label-free biosensing applications. It outperforms other conventional label-free detection methods in terms of portability and parallelization. he objective of this thesis is to investigate the coupling between self-assembled monolayers (SAMs) interactions and microcantilever responses. To this end, a dual compact optical microcantilever sensing platform was built to ease conducting biosensing experiments in gas-phase environments or in solutions. The thermal bimorph effect was used and found to be an effective nanomanipulator for the microcantilever platform calibration. he study of the alkanethiol SAM chain length effect revealed that the 1-octanethiol (C8H17SH) induced larger deflection than that from 1-dodecanethiol (C12H25SH) and 1-tetradecanethiol (C14H29SH) in solutions. We also observed that higher concentration of SAMs in solutions led to higher surface stresses. In comparing with absorption experiments conducted in air and in solutions, we observed significant change of surface stresses.n surface characterization part, by using the XRD (X-Ray Diffraction) analysis, we found that the gold surface was dominated by the (111) crystalline plane. With the XPS (X-ray Photoelectron Spectroscopy) analysis, we confirmed that the Au-S covalent bonds were occurred in SAM absorption.
Subjects
biosensing
microcantilever
self-assembled monolayers
surface stress
surface characterization
Type
thesis
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