Fixed erythrodysaesthesia plaque due to gemcitabine and epirubicin treatment [8]
Journal
Acta Dermato-Venereologica
Journal Volume
82
Journal Issue
2
Pages
147-148
Date Issued
2002
Author(s)
Abstract
Sir, infusion of gemcitabine and epirubicin. Furthermore, the patient had no clinical picture of acral erythema. Fixed erythrodysaesthesi a plaque (FEP) is a unique cutaneous reaction due to intravenous injection of doceOne skin biopsy undertaken on the left arm lesion showed epidermal dysmaturation, frequent dyskeratosis, taxel. It presents as xed erythematous plaque(s) unrelated to extravasation or previous skin injury (1). interface dermatitis, pigment incontinence and a super cial dermal perivascular mononuclear cell in ltrate Gemcitabine (di uorodeoxycytidine , 2’,2’-di uorodeoxycytidine; dFdC) is a deoxycytidine analogue with (Fig. 2). Betamethasone valerate cream and salicylate ointment were given as topical therapy. The plaques structural and metabolic similarities to cytarabine (ara-C ) (2). It mimics the structure of the natural became desquamated, crusted and their colour darkened to brown. One month later, all the skin lesions resolved nucleoside and, following phosphorylation, is incorporated into DNA (3). Several previous reports have with only slight hyperpigmentation . No recurrence of the skin lesions was noted even though the patient shown that gemcitabine alone or in combination with cisplatin is active against non-small-cell lung cancer (NSCLC) with little cutaneous toxicities (4–6). Epirubicin is the 4’ epimer of the anthracycline antibiotic doxorubicin (7). A combination of epirubicin and gemcitabine has been reported to be eVective in treating patients with advanced NSCLC (8). We report the development of FEP on both forearms of a patient treated with gemcitabine and epirubicin.
SDGs
Other Subjects
betamethasone valerate; cisplatin; dicloxacillin; epirubicin; gemcitabine; salicylic acid; antineoplastic agent; deoxycytidine; docetaxel; drug derivative; epirubicin; gemcitabine; paclitaxel; taxoid; adult; bone metastasis; cancer combination chemotherapy; case report; clinical feature; cream; drug effect; drug induced disease; drug response; dysesthesia; erythema; hand foot syndrome; histopathology; human; human tissue; letter; lung adenocarcinoma; male; pleura effusion; priority journal; skin biopsy; symptom; adenocarcinoma; chemically induced disorder; drug eruption; erythema; intravenous drug administration; lung tumor; middle aged; paresthesia; pathology; skin; Adenocarcinoma; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Case Report; Deoxycytidine; Drug Eruptions; Epirubicin; Erythema; Human; Infusions, Intravenous; Lung Neoplasms; Male; Middle Age; Paclitaxel; Paresthesia; Skin; Adenocarcinoma; Antineoplastic Agents, Phytogenic; Humans; Infusions, Intravenous; Lung Neoplasms; Male; Middle Aged; Skin; Taxoids
Type
letter