SECULAR TRENDS AND GEOGRAPHIC VARIATIONS OF HEPATITIS B VIRUS AND HEPATITIS C VIRUS-ASSOCIATED HEPATOCELLULAR CARCINOMA IN TAIWAN
Resource
INTERNATIONAL JOURNAL OF CANCER v.119 n.8 pp.1946-1952
Journal
INTERNATIONAL JOURNAL OF CANCER
Journal Volume
v.119
Journal Issue
n.8
Pages
1946-1952
Date Issued
2006
Date
2006
Author(s)
LU, SHENG-NAN
SU, WEI-WEN
YANG, SHENG-SHUN
CHANG, TING-TSUNG
CHENG, KEN-SHENG
WU, JAW-CHING
LIN, HANS, HSIEN-HONG
WU, SHUN-SHENG
LEE, CHUAN-MO
CHANGCHIEN, CHI-SIN
CHEN, CHIEN-JEN
SHEU, JIN-CHUAN
CHEN, DING-SHINN
Abstract
Etiological variations in hepatocellular carcinoma (HCC) exist across different geographic areas. To gain better control of HCC, we retrospectively studied the secular trends and geographic variations in hepatitis B virus (HBV)- related and hepatitis C virus (HCV)-related HCCs in Taiwan. A total of 18,423 HCC cases enrolled in 8 medical centers from 1981 to 2001 were reviewed. Overall, 67% of male HCC in Taiwan was related to HBV infection whereas 55.2% of female HCC in Taiwan was related to HCV infection. The mean age of patients with HBV-related HCC was 53.2 +/- 13.6 years, while the mean age of patients with HCV-related HCC was 65.1 +/- 9.1 years (p < 0.001). The male/female ratio was 6.4 for HBV-related HCC, while it was 1.7 for the HCV-related HCC ( p < 0.001). The percentage of HBV-related HCC progressively decreased from 81.5 to 66.2% in males, and from 66.7 to 41. 4% in females over the study period. Our study demonstrates that the percentage of HBV-related HCC has progressively decreased over the last 20 years. The relative decrease in HBV-related HCC was not due to a decrease in HBV-related HCC death. Instead, it was caused by an increase in HCV-related HCC. Prevention of new HCV infection and the treatment of chronic hepatitis C should be the primary goals, which will result in better control of HCC in the future, even in an HBV-endemic area like Taiwan.( c) 2006 Wiley-Liss, Inc.
Subjects
hepatocellular carcinoma
hepatitis B virus
hepatitis C virus
secular trend
geographic variation
Taiwan
SDGs
Type
journal article