Precancerous esophageal epithelia are associated with significantly increased scattering coefficients
Journal
Biomedical Optics Express
Journal Volume
6
Journal Issue
10
Pages
3795-3805
Date Issued
2015
Author(s)
Su J.-W.
Lin Y.-H.
Hsieh C.-M.
Yang P.-W.
Wang C.-P.
Sung K.-B.
Abstract
The progression of epithelial precancers into cancer is accompanied by changes of tissue and cellular structures in the epithelium. Correlations between the structural changes and scattering coefficients of esophageal epithelia were investigated using quantitative phase images and the scattering-phase theorem. An ex vivo study of 14 patients demonstrated that the average scattering coefficient of precancerous epithelia was 37.8% higher than that of normal epithelia from the same patient. The scattering coefficients were highly correlated with morphological features including the cell density and the nuclear-to-cytoplasmic ratio. A high interpatient variability in scattering coefficients was observed and suggests identifying precancerous lesions based on the relative change in scattering coefficients. ? 2015 Optical Society of America.
SDGs
Other Subjects
Cell density; Cellular structure; Ex-vivo; Highly-correlated; Morphological features; Nuclear-to-cytoplasmic ratios; Phase image; Scattering co-efficient; Optical constants; anisotropy; Article; cell density; controlled study; correlation analysis; electron tomography; esophagus mucosa; histology; human; human tissue; image analysis; light related phenomena; precancer; scattering coefficient; scattering phase theorem; statistical analysis; validation study
Publisher
OSA - The Optical Society
Type
journal article