Radiosensitization effect by HDAC inhibition improves NKG2D-dependent natural killer cytotoxicity in hepatocellular carcinoma
Journal
Frontiers in oncology
Journal Volume
12
Date Issued
2022-09
Author(s)
Abstract
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide. Radiotherapy (RT) controls HCC unsatisfactorily and temporarily. Histone deacetylase inhibitor (HDACi) is a heterogeneous group of epigenetic therapeutics with promising anticancer effects and synergism in combination with RT. HDACi modulates natural killer (NK) cell ligand expression on tumor cells, and leads to immune evasion of cancer cells. Expressions of NK group 2D (NKG2D) ligands on cancer cells determine the cytotoxic effect by interacting with NKG2D receptor on NK cells. However, the role of NKG2D signaling in HCC upon combined RT and HDACi remains unclear.
Subjects
NK cell-mediated cytotoxicity; NKG2D ligand; hepatocellular carcinoma; histone deacetylase inhibition; radiotherapy
SDGs
Publisher
FRONTIERS MEDIA SA
Type
journal article